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Project 8p Research Newsletter – October 2023

Project 8p is looking for companies and researchers working on novel technologies for augmentative devices.

Project 8p Research Newsletter – September 2023

Do you know a researcher who should be part of the Project 8p Research Network? 

Skin deep

Disease modeling in 8p brain organoids led to the discovery of Reelin as a novel potential driver gene. Will skin cells from 8p heroes teach us about the disease and lead to treatments? We think so.

Project 8p – Research Newsletter August 2023

Chromosome 8p inversions, duplications, and deletions arise due to the presence of a gene cluster called the beta-defensin locus (Floridia et al. AJHG 1996).

GLOBAL GENES – ACE’S ADVENTURE WITH A RARE DELETION ON CHROMOSOME 8

Just by his smile, everybody knows our beautiful two year old son Aaron, or as we call him, our Ace. He’s…

Project 8p Research Newsletter – July 2023

This month’s Research Roundtable featured 8p researcher Dr. Jason Sheltzer from the Yale University School of Medicine. Dr. Sheltzer and his group are working on a project aimed at restoring normal chromosome copy number (disomy) in 8p iPS cells

Project 8p Research Newsletter – June 2023

Large chromosomal copy number variants, such as trisomy 21 and 8p duplication/deletion, affect the expression of a large number of genes. A fundamental question is how do these changes in gene expression give rise to the cellular and developmental phenotypes that are characteristic of these syndromes?
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The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.
  • Lead with knowledge from patients. Currently, there is no cure for 8p disorders, nor is there a standard course of treatment.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Raise transformative funding for pioneering scientific research into treatments for a complex, rare disease involving 250+ affected genes on the short arm of the 8 th chromosome (8p). Rearrangements of these genes causes significant abnormalities to the entire neurological system, thus all organs and functions of the body– with variance in cognitive functions, gross motor skills, social development and other challenges during infancy, and throughout life;
  • Empower a unified community of 8p patients and their families so they can have meaningful lives today; and
  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.