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A Grand Unified Theory of Neurodevelopmental Chromosomal Disorders

Project 8p’s quest is to mend broken chromosomes. By making medicines for 8p heroes living with the fallout of genomic imbalance we might just solve one of biology’s most complex puzzles.

The p in 8p is short for petit but it could easily stand for puzzle. 

In analogy to Newtonian mechanics failing to predict the composition and motion of subatomic particles, the classical frameworks of aneuploidy fail to pinpoint a minimal set of common driver genes that are responsible for the shared constellation of symptoms and disabilities experienced by all 8p heroes who suffered a pre-conception traumatic genome injury to the short arm of the maternal copy of chromosome 8.

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The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.
  • Lead with knowledge from patients. Currently, there is no cure for 8p disorders, nor is there a standard course of treatment.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Raise transformative funding for pioneering scientific research into treatments for a complex, rare disease involving 250+ affected genes on the short arm of the 8 th chromosome (8p). Rearrangements of these genes causes significant abnormalities to the entire neurological system, thus all organs and functions of the body– with variance in cognitive functions, gross motor skills, social development and other challenges during infancy, and throughout life;
  • Empower a unified community of 8p patients and their families so they can have meaningful lives today; and
  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.