Disease modeling in 8p brain organoids led to the discovery of Reelin as a novel potential driver gene. Will skin cells from 8p heroes teach us about the disease and lead to treatments? We think so.
Project 8p is the world’s first nonprofit biotech whose mission is to lead the charge toward treatments and cures for complex chromosome diseases caused by megabase rearrangements. Pick your flavor combo: deletion, duplication, and even inversion. 8p heroes can have all three, including heroes who just have an 8p deletion or an 8p duplication.
For some perspective on scale, and as another reminder why 8p is particularly challenging: you can fit an entire copy of human chromosome 21, which encodes several hundred genes, inside a single typical 8p duplicated segment.