Project 8p Research Newsletter – May 2024

Project 8p funded Professor Warmflash’s lab to study early fetal development in the lab using induced pluripotent stem cells (iPSCs) derived from 8p heroes. The Warmflash lab specializes in a technique called the germ layer micropatterning assay, which offers a window into how the growing embryo organizes itself. 

A quick refresher on developmental biology. All organ systems of the body originate from one of the three germ layers: ectoderm (outer layer), mesoderm (middle layer), and endoderm (inner layer). The endoderm gives rise to digestive and respiratory systems. The mesoderm gives rise to the skeleton, muscle, heart and bones. The ectoderm births the nervous system and the skin.

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The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.
  • Lead with knowledge from patients. Currently, there is no cure for 8p disorders, nor is there a standard course of treatment.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Raise transformative funding for pioneering scientific research into treatments for a complex, rare disease involving 250+ affected genes on the short arm of the 8 th chromosome (8p). Rearrangements of these genes causes significant abnormalities to the entire neurological system, thus all organs and functions of the body– with variance in cognitive functions, gross motor skills, social development and other challenges during infancy, and throughout life;
  • Empower a unified community of 8p patients and their families so they can have meaningful lives today; and
  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.