This month’s Research Roundtable featured 8p researcher Dr. Jason Sheltzer from the Yale University School of Medicine. Dr. Sheltzer and his group are working on a project aimed at restoring normal chromosome copy number (disomy) in 8p iPS cells. The primary goal of this work is to create pairs of cell lines where the only difference between them is the 8p rearrangement (so-called “isogenic lines”). This will allow researchers to separate the impacts of the 8p CNV from those of the background genetic variation when it comes to studying the cellular biology of 8p or performing drug screens. In addition, this research will also help pave the way for chromosome therapies that can eventually be applied in vivo.