Chromosome 8p inversions, duplications, and deletions arise due to the presence of a gene cluster called the beta-defensin locus (Floridia et al. AJHG 1996). This locus is flanked by repetitive sequences on both ends, which have the potential to misalign and undergo recombination during meiosis I, causing the chromosome to break. Where the chromosome breaks can be different each time, resulting in breakpoints that are unique to each 8p hero.  Â
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