What happens when preliminary data from two independent model systems line up? Is it case closed, or just the beginning of a careful iterative process to determine which results are real and which results are not, i.e, false positives? In this case, one model is three-dimensional cortical brain organoids grown in the lab for nine months, and the other model is two-dimensional glutamatergic neurons grown in the lab for three weeks. As much as we want to believe initial positive results, they have to be rigorously repeated and pressure-tested. For any iPSC-derived model, it’s imperative to use multiple independent clones or models from additional 8p hero- derived samples.