Balancing Act

One day science will restore balance to the genomes of 8p heroes. It will be a long, arduous journey. The first step toward a curative chromosome therapy can be summed up as: aneuploidy, heal thyself.

Since the dawn of life three billion years ago up to this very moment, chromosomes perform a timeless microscopic Cirque du Soleil inside the nucleus of every mother cell that is poised to divide into two daughter cells. This improbable performance has repeated trillions upon trillions of times across the tree of life over our collective evolutionary history. Critically, the genetic material in a mother cell — in the case of humans, 23 pairs of chromosomes — must be evenly bequeathed to her two daughter cells. Otherwise, the genome is out of balance and the consequences can be catastrophic.

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The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.
  • Lead with knowledge from patients. Currently, there is no cure for 8p disorders, nor is there a standard course of treatment.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Raise transformative funding for pioneering scientific research into treatments for a complex, rare disease involving 250+ affected genes on the short arm of the 8 th chromosome (8p). Rearrangements of these genes causes significant abnormalities to the entire neurological system, thus all organs and functions of the body– with variance in cognitive functions, gross motor skills, social development and other challenges during infancy, and throughout life;
  • Empower a unified community of 8p patients and their families so they can have meaningful lives today; and
  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.