Project 8p has a grant program that accepts unsolicited LOI’s here as well as a publicly posted general Request for Proposal (RFP) that provides detail regarding a general area of interest, sets timelines for review and approval, and uses an expert review panel to make final grant decisions.

We are committed to sharing biospecimens, cell lines, animal models, and de-identified data.  

Aligned with Project 8p’s mission of translational research is our ability to fund and welcome partnerships to take clinical action. With quality data sharing, transparency, and access to our iPSC lines and models, we encourage researchers around the world to help us discover clinically relevant, medically actionable, stretch of DNA that is the key to help individuals affected by genetic disease, and the “future of medicine” for 8p disorders.

We also echo the main goals of the Human Genome Project (HGP) to develop new, better and cheaper tools to identify new genes and to understand their function. The same goal applies to chromosomes and driver genes. We invite researchers to help us identify therapeutic targets, downstream and driver casual genes, functional assays for the most important phenotypes and symptoms, and develop treatments and possible prevention of this disorder. We do not know how this manifests into adulthood. What if we could prevent symptoms that manifest later in life?

We are pragmatic and impatiently patient about the unknown timeline; therefore, we want to start now and be ready to take advantage of the future of genome medicine.

Funding great research begins with a focus on people and projects

Our Research Roadmap guides our work to address the critical knowledge gaps, advance discovery, and encourage Team Science within 8p disorders and neurodevelopmental chromosome disorders or aneuploidy.

The principles of Open Science promote a greater sharing of information, data and materials leading to enhanced understanding of disease biology.

Review Criteria

When reviewing a proposal, the committee members are asked to consider the extent to which the proposed research meets the following criteria. The committee recognizes that some of these criteria will not apply to all research proposals.

Our programs aim to foster outstanding science across disciplines, fields, and career stages — and provide resources (see Phenotypic Data and Biospecimens available) for our awardees to succeed.

Research focuses on issues and concerns that are known or believed to be considered important by people with chromosome 8p or related disorders.

Research is scientifically rigorous.

If applicable, new data is feasible to collect (for proposals that involve obtaining additional data not already collected via the Chromosome 8p Registry).

Research has the potential to definitively answer an important question.

The willingness of the investigator to publish and share their findings with the broader scientific community

For biospecimens only: The ability to successfully complete a material transfer agreement (MTA) with the Project 8p Foundation. Additionally, the type of samples requested and the quantity available may determine whether biospecimens are transferred.

Research focuses on issues and concerns that are known or believed to be considered important by people with chromosome 8p or related disorders.

Research is scientifically rigorous.

If applicable, new data is feasible to collect (for proposals that involve obtaining additional data not already collected via the Chromosome 8p Registry).

Research has the potential to definitively answer an important question.

The willingness of the investigator to publish and share their findings with the broader scientific community

For biospecimens only: The ability to successfully complete a material transfer agreement (MTA) with the Project 8p Foundation. Additionally, the type of samples requested and the quantity available may determine whether biospecimens are transferred.

Once an LOI is considered, we will then provide full Application Instructions.

  • We are accepting RFPs. Please contact us at info@project8p.org.
  • We are committed to sharing biospecimens, cell lines, animal models, and de-identified data.

Grant Indirect Cost Policy

  • The key differentiating factor between “direct” and “indirect” costs is whether the cost is specifically required for the project or program to meet its objectives:
  • Direct costs are expenses directly incurred for the specific project or program being funded. Examples include salaries for program staff, travel expenses, materials, consultants required to execute the grant. Expenses like these would not be incurred if the project or program did not exist.
  • Indirect costs are overhead and administration expenses necessary to support an organization’s general operation, which are thus shared across projects or programs.
  • Examples include rent and utilities, office furniture, computers and information systems, and the costs of functions like development, finance and accounting, IT, HR, and legal. Expenses like these would be incurred in some amount with or without a specific project or program grant. Indirect costs are those for activities or services that benefit more than one project. Their precise benefits to a specific project are often difficult or impossible to trace.
  • Policy For Universities: Project 8p recognizes that grant award recipients may have overhead costs that are not directly attributable to the proposed project but are necessary to carry out the proposed project. Project 8p will not fund indirect costs, and therefore can only make grants to researchers and institutions that can absorb the indirect costs of the project. Grantees should discuss such an exception prior to submitting proposals.
  • While the definitions above provide general guidance, Project 8p reserves the right to review all costs and budget assumptions on a grant by grant basis.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.
  • Lead with knowledge from patients. Currently, there is no cure for 8p disorders, nor is there a standard course of treatment.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Raise transformative funding for pioneering scientific research into treatments for a complex, rare disease involving 250+ affected genes on the short arm of the 8 th chromosome (8p). Rearrangements of these genes causes significant abnormalities to the entire neurological system, thus all organs and functions of the body– with variance in cognitive functions, gross motor skills, social development and other challenges during infancy, and throughout life;
  • Empower a unified community of 8p patients and their families so they can have meaningful lives today; and
  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.