The elusive 8p minimal critical region

Megabase alterations to the short arm of chromosome 8 are a plot to overthrow the organism, not the actions of a lone wolf. A whodunit orchestrated by a shadowy web of co-conspirators, double agents, and unwitting patsies. Innocent bystanders get swept up in the confusion. Everyone in a defined radius is under suspicion.

The evidence collected is often circumstantial, no obvious smoking gun. There are too many leads to chase down, most of them dead ends, and not enough investigators assigned to the case. The manhunt to round up driver genes feels like a race against time.

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The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.
  • Lead with knowledge from patients. Currently, there is no cure for 8p disorders, nor is there a standard course of treatment.

The Project 8p Foundation (Project 8p) was created in 2018 to:

  • Raise transformative funding for pioneering scientific research into treatments for a complex, rare disease involving 250+ affected genes on the short arm of the 8 th chromosome (8p). Rearrangements of these genes causes significant abnormalities to the entire neurological system, thus all organs and functions of the body– with variance in cognitive functions, gross motor skills, social development and other challenges during infancy, and throughout life;
  • Empower a unified community of 8p patients and their families so they can have meaningful lives today; and
  • Accelerate future treatments, not only for 8p, but potentially for other chromosome-wide diseases as well.