Megabase alterations to the short arm of chromosome 8 are a plot to overthrow the organism, not the actions of a lone wolf. A whodunit orchestrated by a shadowy web of co-conspirators, double agents, and unwitting patsies. Innocent bystanders get swept up in the confusion. Everyone in a defined radius is under suspicion.
The evidence collected is often circumstantial, no obvious smoking gun. There are too many leads to chase down, most of them dead ends, and not enough investigators assigned to the case. The manhunt to round up driver genes feels like a race against time.